Product Name: 2-Chloro-5-nitropyridine
Cas No.: 4548-45-2
Molecular Formula: C5H3ClN2O2
Molecular Weight: 158.54
Appearance: White powder
Density: 1.489
Purity: 99% Min
Solubility: Soluble in hot methanol. sparingly soluble in water.
Boiling point: 256.6 °C at 760 mmHg
Melting point: 106-110℃
Flash point: 109 °C
Vapour: 0.02mmHg at 25°C
Refractive index: 1.587
SMILES: N(=O)(=O)C=1C=CC(Cl)=NC1
InChI Key: InChIKey=BAZVFQBTJPBRTJ-UHFFFAOYSA-N
Other Names: 6-Chloro-3-nitropyridine / 5-Nitro-2-chloropyridine / NSC 4468

Description:

2-Chloro-5-nitropyridine, also known as 6-Chloro-3-nitropyridine, 5-Nitro-2-chloropyridine or NSC 4468, is widely used as an intermediate in the synthesis of various pharmaceuticals (like Sonidegib), agrochemicals, and other organic compounds. Its functional groups make it a versatile building block for the introduction of specific chemical moieties during synthesis. The presence of the chloro and nitro groups allows for further chemical modifications and reactions, leading to the creation of more complex molecules.

Due to its reactivity and versatility, 2-Chloro-5-nitropyridine finds applications in the pharmaceutical industry for the synthesis of drugs and active pharmaceutical ingredients (APIs). It is also utilized in the production of agrochemicals, dyes, pigments, and other fine chemicals.

It is important to handle 2-Chloro-5-nitropyridine with care, following proper safety protocols and guidelines, as it can be harmful if ingested, inhaled, or in contact with the skin.

Features:

1. Chemical properties: 2-Chloro-5-nitropyridine is a white crystalline solid with a distinctive odor. It has a molecular formula of C5H3ClN2O2 and a molecular weight of 158.54 g/mol. It is sparingly soluble in water but soluble in organic solvents such as ethanol, methanol, and acetone.
2. Functional groups: The compound contains both a chlorine atom (Cl) and a nitro group (NO2) attached to the pyridine ring. These functional groups provide reactivity and enable the compound to participate in various chemical reactions.
3. Reactivity: 2-Chloro-5-nitropyridine is reactive and can undergo substitution, reduction, and other chemical transformations. The presence of the chlorine and nitro groups allows for further derivatization and modification to create new compounds with desired properties.
4. Versatility: Due to its reactivity and functional groups, 2-Chloro-5-nitropyridine serves as a versatile building block in organic synthesis. It can be used as an intermediate to synthesize a wide range of pharmaceuticals, agrochemicals, dyes, and other fine chemicals.

Applications:

1. Pharmaceutical synthesis
2-Chloro-5-nitropyridine serves as a valuable intermediate in the synthesis of various pharmaceutical compounds (like Sonidegib). It can be used in the production of antihypertensive drugs, antimicrobial agents, anti-inflammatory drugs, and other therapeutically active substances.
2. Agrochemicals
The compound finds use in the synthesis of agrochemicals such as herbicides, insecticides, and fungicides. These agricultural chemicals play a crucial role in crop protection and pest control, contributing to improved agricultural yields and quality.
3. Dye synthesis
2-Chloro-5-nitropyridine is utilized in the production of dyes and pigments. It can be incorporated into dye molecules to impart specific colors and properties, making it valuable in the textile, printing, and dyeing industries.
4. Chemical research
The compound is utilized in chemical research as a versatile building block and reagent. Its reactivity and functional groups allow chemists to create and modify molecules for various research purposes, including the development of new materials, catalysts, and chemical processes.
5. Other applications
2-Chloro-5-nitropyridine may have applications in other areas such as electrochemistry, polymer synthesis, and organic electronics. Its unique chemical properties make it useful in diverse scientific and industrial fields.

Storage: Keep in dark place, sealed in dry, room temperature.

Package: 25kg/bag or as per your particular request.